Cardiac adaptations to high-altitude hypoxia in deer mice

We are examining the ability of the heart to sustain blood pressure and flow during low oxygen conditions in high-altitude deer mice. Several experiments, some completed and some ongoing, are measuring cardiovascular physiology using a variety of techniques that merge our collective expertise (vascular surgery, blood pressure using arterial catheters, in vivo pressure-volume loop catheters in the left and right ventricles).