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PARITY

  Faculty of Health Sciences - Surgery,

  Michelle Ghert (ghert@hhsc.ca), Mohit Bhandari (bhandam@mcmaster.ca), Gordon Guyatt (guyatt@mcmaster.ca), Lehana Thabane (thabanl@mcmaster.ca), Tim O'Shea (osheat@mcmaster.ca), Tricia Schneider (schnep@mcmaster.ca), Paula McKay (mckayp@mcmaster.ca)

  Status
Ongoing
  Start Date
January, 2012
  Countries
Argentina, Australia, Brazil, Canada, India, Netherlands, South Africa, Spain, United States of America

The Prophylactic Antibiotic Regimens In Tumor SurgerY (PARITY) trial is an ongoing international, multi-centre, double-blind, randomized controlled trial evaluating the efficacy of short- versus long-term post-operative prophylactic antibiotic regimens on the incidence of surgical site infection following endoprosthetic reconstruction of lower extremity bone tumors. Enrolment for the PARITY pilot phase was completed in October 2014 and the study immediately progressed into the definitive phase. The pilot manuscript was published in Bone and Joint Research in September 2015.

Impact

To our knowledge, this is the first randomized controlled trial in orthopaedic surgical oncology and has led to newly forged collaborations with surgeons at 36 international sites in the United States, Argentina, Australia, South Africa, Brazil, Spain, the Netherlands and India.

Student Experience

This project provides a unique opportunity to foster and support a culture of inquiry for novice investigators via the mentorship from senior staff in the McMaster University surgeon-scientist program. One orthopaedic surgery resident acted as the PARITY Scientific Officer while completing his PhD.

Countries
Argentina, Australia, Brazil, Canada, India, Netherlands, South Africa, Spain, United States of America
Impact
Research, Global Partnerships
Institutional Partner(s)
Fundació Hospital Universitari Vall d’Hebron Institut de Recerca
Community Partner(s)
Industry Partner(s)
Key Outcomes
Publications
Sponsorship
Federal
Provincial
Municipal
Community
Sponsorship Details
Canadian Cancer Society Research Institute, Orthopaedic Research and Education Foundation/Musculoskeletal Tumor Society, Canadian Institutes of Health Research, McMaster Surgical Associates, Physicians’ Services Inc. Foundation.
MOU
Yes

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