To compare the efficacy of a shorter course of radiotherapy with a conventional fractionation course with respect to biochemical failure defined by a cluster of events including PSA progression, clinical evidence of local or metastatic progression (nodal or distant), post-treatment initiation of hormonal therapy by the treating physician or prostate cancer related death. The study includes men with histologic diagnosis of carcinoma of the prostate within the last 6 months without evidence of metastatic disease to the lymph nodes, bone or lung.
Impact
Modern radiotherapy practice toward highly conformed, high precision radiotherapy techniques for prostate cancer treatment has reduced treatment toxicity and improved biochemical relapse free rates with dose-escalation. Treatment times have extended which has increased radiotherapy requirements without increasing capacity and placed a social, emotional and economic burden on patients. This study provides an opportunity to show that shorter treatment courses, if safe would reduce these burdens.
Student Experience
No student involvement.
Countries
Australia, Canada, France, New Zealand
Impact
Research
Institutional Partner(s)
CIHR, TROG, Participating Clincial Centres (Hospitals and Cancer Centres)
